The Entourage Effect
The entourage effect in cannabis refers to the synergistic interaction between the various compounds found in the plant, including cannabinoids (like THC and CBD), terpenes, and flavonoids, which together enhance or modify the effects compared to when each compound is used in isolation. Essentially, it means that the whole plant’s compounds work better together than any single compound does on its own.
Key Points:
Cannabinoids: The most well-known are THC (psychoactive) and CBD (non-psychoactive), but there are over 100 others, such as CBG and CBN. These cannabinoids bind to receptors in the body and brain, influencing mood, pain, and inflammation.
Terpenes: These aromatic compounds not only give cannabis its distinct smell and flavor but also influence its effects. For example, some terpenes can enhance the relaxing properties of certain strains, while others may increase alertness.
Flavonoids: While less discussed, flavonoids also contribute to the plant’s color and provide antioxidant and anti-inflammatory benefits.
Example of the Entourage Effect:
THC and CBD: THC alone can cause anxiety in some users, but when CBD is present, it can counteract this effect, making the experience more balanced. In this way, the combination of cannabinoids produces a more nuanced effect than THC alone.
Terpenes: A terpene like myrcene, known for its sedative qualities, can enhance the calming effects of certain cannabis strains when combined with THC and CBD.
Why It Matters:
The entourage effect suggests that cannabis-based therapies might be more effective when a full spectrum of compounds is used (such as in full-spectrum or broad-spectrum products) compared to isolated cannabinoids like pure THC or CBD. This is why many users and medical professionals prefer whole-plant extracts over isolates.
In short, the entourage effect highlights the complexity of cannabis and the importance of its naturally occurring compounds working together to produce more balanced and effective outcomes.
